Genome Integrity: Facets and Perspectives: 1 (Genome Dynamics and Stability)


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IJMS | Special Issue : Mechanisms Leading to Genomic Instability

In that spirit, the talks will cover a broad range of areas, including, but not limited to the DNA damage response and cancer predisposition, DNA replication, transcription, chromatin modification, recombination, cell cycle control, telomeres, chromosome segregation, epigenetic states, as well as the emergence of new technologies relevant to research in genome integrity. Although a primary focus is upon basic mechanisms and processes, these areas are pertinent to cancer and myriad human disease states, and it is expected that this will be reflected in the substance of our discussions.

This meeting will include a scientific symposium from to PM, followed by a networking reception from to PM.

Her research is focused on human telomeres and the mechanisms that control their function in normal cells, stem cells, and cancer. In particular she is studying shelterin, the six-subunit complex that coats telomere repeats and tankyrase 1, a poly ADP-ribose polymerase that associates transiently with telomeres. In addition to being program coordinator in the Skirball Institute, she is director of the NYU genome integrity training program. There, she found that the condensin-like dosage compensation complex represses transcription by binding to transcriptionally active promoters on the X chromosome in C.

Currently Sevinc studies the molecular mechanisms by which Structural Maintenance of Chromosomes SMC protein complexes that include condensin and cohesin regulate chromosome structure and transcription. She has authored over publications in molecular and evolutionary biology and edited 3 books, in areas ranging from genetics and evolution to biological computation. Recent awards include a Guggenheim fellowship and a Blavatnik award for young scientists , and she was elected a Fellow of AAAS for probing the diversity of genetic systems in microbial eukaryotes, including scrambled genes, RNA editing, variant genetic codes, and comparative genomics.

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Her work investigates the origin of novel genetic systems. Recent discoveries include the ability of small and long non-coding RNA molecules to transmit heritable information across generations, bypassing the information encoded in DNA. Nikola P.

2 editions of this work

While pursuing her PhD, she focused on the structure and function of the epigenetics gene silencers known as Polycomb Group proteins, and was particularly interested in the assembly and targeting of the Polycomb repression complex 1 related complexes. During her postdoctoral training, she has focused on the structural biology of FAN1 Nuclease and its mechanism of DNA interstrand crosslink processing.

David J. Hiro Funabiki's lab at Rockefeller University. He did his graduate work with Dr. His interest in molecular biology began as an undergraduate at Amherst College, under the mentorship of Dr.

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Caroline Goutte. He hails from the great state of New Jersey. Her graduate work identified a novel protein inhibitor of dNTP synthesis and revealed how checkpoint-mediated regulation of dNTP levels impacts growth. Parker et al.

Cellular responses to DNA strand breaks

Published online: 17 Jan Eva Petermann et al. Cell Cycle Volume 5, - Issue Published online: 14 Sep Dana Branzei et al. Published online: 22 Mar Lisa A. Poole et al.

Published online: 28 Sep Adam R. Leman et al. Cell Cycle Volume 11, - Issue Published online: 17 Sep The multiple facets of the intra-S checkpoint.

What is a Genome? - Brain Waves Episode 7

FAQ Policy. About this book Cells and viruses maintain a genome capable of multiplication, variation and heredity. Show all.

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  • Genome Integrity Discussion Group December 2014;
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